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Glomerulonephritis

Glomerulonephritis (GN) is inflammation of the glomeruli — the filtering units of the kidneys — most commonly caused by immune-mediated injury. It can be acute or chronic and is a significant cause of chronic kidney disease and end-stage renal disease. GN is relevant to massage therapy because it often occurs alongside autoimmune diseases that therapists already manage (lupus, IgA nephropathy), and its systemic effects (edema, hypertension, fatigue, immunosuppression from treatment) require modification.

Recognition

  • Cola-colored or tea-colored urine (hematuria): Classic presentation — blood in urine from damaged glomerular capillaries
  • Foamy urine (proteinuria): Protein leaking through damaged glomerular basement membrane
  • Periorbital edema: Especially in the morning — characteristic of nephrotic presentation
  • Peripheral edema: Worsening throughout the day
  • Hypertension: From fluid retention and RAAS activation
  • Oliguria (reduced urine output) in acute GN
  • Fatigue and malaise
Two clinical syndromes:
  • Nephritic syndrome: Hematuria, mild proteinuria, hypertension, oliguria — indicates active glomerular inflammation
  • Nephrotic syndrome: Heavy proteinuria (> 3.5 g/day), severe edema, hypoalbuminemia, hyperlipidemia — indicates glomerular permeability damage
Common types: Post-streptococcal GN (children, 1-3 weeks after strep throat), IgA nephropathy (most common GN worldwide), lupus nephritis (50% of SLE patients)

MT Relevance

  • Stable, managed GN: Gentle relaxation massage with physician clearance is appropriate. Stress reduction benefits autoimmune-mediated forms.
  • Acute GN with systemic symptoms (fever, severe hypertension, significant edema, oliguria): Massage is contraindicated
  • Nephrotic syndrome: Severe edema makes skin fragile. Immunosuppressive medications increase infection risk — adjust pressure and apply infection precautions
  • Light pressure: Edematous tissue is fragile and bruise-prone. Assess skin integrity before each session.
  • Blood pressure awareness: Monitor. Avoid techniques that significantly increase blood pressure
  • Immunosuppressive medications (mycophenolate, cyclophosphamide, rituximab, corticosteroids): Strict hygiene. Do not treat if the therapist is ill. Corticosteroids cause skin fragility and bruising.
  • Lupus nephritis: Follow lupus-specific protocols in addition to GN considerations
  • ACE inhibitors/ARBs: Reduce proteinuria but cause hypotension — slow position changes

Required Actions

  • Client reports cola-colored urine, new facial swelling, or decreased urine output: Refer for medical evaluation — possible GN flare or new onset
  • Severe hypertension (headache, visual changes) during session: Cease treatment and refer
  • Signs of nephrotic syndrome worsening (massive edema, weight gain, shortness of breath): Urgent medical referral

Key Takeaways

  • Glomerulonephritis is immune-mediated inflammation of the kidney's filtering units
  • Cola-colored urine, periorbital edema, and hypertension are classic presentation features
  • Often secondary to autoimmune diseases (lupus, IgA nephropathy) or post-streptococcal infection
  • Massage is appropriate in stable managed cases but contraindicated during acute flares
  • Immunosuppressive medications require strict infection precautions during massage

Sources

  • Werner, R. (2019). A massage therapist's guide to pathology (7th ed.). Books of Discovery.
  • Norris, T. L. (2019). Porth's essentials of pathophysiology (5th ed.). Wolters Kluwer.
  • Tortora, G. J., & Derrickson, B. H. (2021). Principles of anatomy and physiology (16th ed.). Wiley.