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Congenital Adrenal Hyperplasia (CAH)

★ CMTO Exam Focus

A group of autosomal recessive disorders affecting enzymes required for cortisol biosynthesis in the adrenal cortex. The most common form (95% of cases) is 21-hydroxylase deficiency. Because cortisol synthesis is impaired, negative feedback inhibition of ACTH is lost — elevated ACTH drives adrenal cortex hyperplasia and shunts steroid precursors toward androgen overproduction. CAH ranges from life-threatening salt-wasting crisis in newborns to mild, late-onset forms presenting in adolescence or adulthood with hyperandrogenism (hirsutism, acne, menstrual irregularity).

Recognition

  • Classic salt-wasting (newborns): Vomiting, dehydration, hyponatremia, hyperkalemia, failure to thrive — adrenal crisis within first weeks of life if untreated
  • Classic simple virilizing: Female infants with ambiguous genitalia. Males appear normal at birth but develop early puberty
  • Non-classic (late onset): Females present with hirsutism, irregular menses, acne, and a PCOS-like picture. Males with acne, premature puberty, and reduced fertility
  • Short stature in adults: Androgen-driven premature epiphyseal closure in undertreated childhood CAH
  • Clients on hydrocortisone and fludrocortisone replacement: Confirms active disease management

MT Relevance

  • Adrenal crisis precautions are the primary safety concern — identical to Addison disease. Confirm the client has taken their hydrocortisone before the session. Recognize adrenal crisis (sudden hypotension, nausea, confusion) as a 911 emergency.
  • Orthostatic hypotension: Common with mineralocorticoid deficiency — use slow repositioning. Monitor for dizziness
  • Long-term hydrocortisone effects: Skin thinning, easy bruising, reduced bone density (osteoporosis) — reduce pressure. Avoid deep compression over bony prominences. Avoid aggressive percussion
  • General massage is well-indicated in stable, well-managed CAH — stress reduction supports cortisol regulation and psychological wellbeing
  • Children with CAH: Parental or guardian consent. Age-appropriate communication. Shorter sessions, gentle techniques
  • Refer if the client reports increased salt craving, unusual fatigue, or new dizziness — may indicate suboptimal mineralocorticoid replacement

Required Actions

  • Adrenal crisis signs (sudden hypotension, nausea, confusion, collapse): Call 911; administer client's emergency hydrocortisone if available
  • Client has not taken hydrocortisone: Postpone the session until medication is taken
  • New salt craving, unexplained fatigue, or dizziness: Refer to endocrinologist — possible dose adjustment needed

Key Takeaways

  • CAH is a congenital enzyme deficiency in cortisol synthesis resulting in adrenal hyperplasia and androgen excess
  • The primary MT safety concern is adrenal insufficiency: cortisol-dependent stress response is compromised — same precautions as Addison disease
  • Adrenal crisis (sudden hypotension, nausea, confusion) is a 911 emergency in CAH clients on hydrocortisone
  • Long-term corticosteroid replacement causes skin thinning, bruising, and osteoporosis — reduce pressure accordingly
  • Stable, well-managed CAH is compatible with regular massage. Align treatment with medication timing

Sources

  • Werner, R. (2019). A massage therapist's guide to pathology (7th ed.). Books of Discovery.
  • Norris, T. L. (2019). Porth's essentials of pathophysiology (5th ed.). Wolters Kluwer.
  • Tortora, G. J., & Derrickson, B. H. (2021). Principles of anatomy and physiology (16th ed.). Wiley.
  • Rattray, F., & Ludwig, L. (2000). Clinical massage therapy: Understanding, assessing and treating over 70 conditions. Talus Incorporated.